Domestic and T20 Career

He was included in the North West cricket team's squad for the 2015 Africa T20 Cup. In August 2017, he was named to the Cape Town Knight Riders roster for the inaugural season of the T20 Global League. However, in October 2017, Cricket South Africa initially postponed the tournament to November 2018 and canceled it shortly thereafter.

In October 2018 he was called up to the Jozi Stars squad for the first edition of the Mzansi Super League T20 tournament. In April 2019, Pretorius was signed by Northamptonshire to play in the 2019 t20 Blast tournament in England.

In July 2019 he was selected to play for the Edinburgh Rocks in the inaugural edition of the Euro T20 Slam cricket tournament. However, the following month the tournament was cancelled. In September 2019, he was named to the Paarl Rocks squad for the 2019 Mzansi Super League Tournament. In December 2019, he was drafted by the Pakistan Super League (PSL) franchise team Peshawar Zalmi as a Silver Category Pick in the 2020 PSL Draft.
In April 2021 he was called up to the North West squad ahead of the 2021–22 South Africa cricket season.

Dwaine Pretorius IPL 2022 In February 2022, he was bought by the Chennai Super Kings at auction for the 2022 Indian Premier League Tournament.

International Career

Pretorius made his international debut for South Africa against Ireland in a One Day International on 25 September 2016. 1 for 19 with the ball and didn't have to bat in South Africa's 206-run win.

In September 2016, Pretorius was included in the One Day International squad for their series against Australia in South Africa after Chris Morris suffered a knee injury.

Pretorius made his second international appearance in the 3rd ODI against Australia. He took 0-42 from six overs and hit 15 balls from 20 as the team chased 371 to beat Australia. Pretorius was also selected to play Australia in the 4th ODI, claiming the wicket from George Bailey. Return numbers 1-33 from 7 overs. He did not have to bat in South Africa's innings and was not selected to play in the 5th ODI as South Africa overwhelmed Australia 5–0.
In November 2016, Pretorius was included in the South Africa Test squad for the series against Australia. He replaced Dale Steyn, who suffered a shoulder injury in the first Test. In June 2017 he was called up to South Africa's Twenty20 International (T20I) squad for the series against England. He made his T20I debut for South Africa against England on 21 June 2017. In April 2019 he was called up to South Africa's squad for the 2019 Cricket World Cup. He was called up to the South Africa Test squad for their run against England in December 2019. He made his Test debut for South Africa against England on 26 December 2019. In March 2020, he was awarded a national contract by Cricket South Africa ahead of the 2020–21 season.

On 13 February 2021, during the series against Pakistan, Pretorius scored his first five-wicket draw in T20Is with 5/17. These were also the best numbers by a bowler for South Africa in a T20I match. In September 2021, Pretorius was named to South Africa's squad for the 2021 ICC Men's T20 World Cup.